NOTES

A family history is defined as a history of Classical CJD (Sporadic CJD) or other Transmissible Spongiform Encephalopathy (TSE) in any blood relative. A family history of variant CJD is not a reason for deferral

 ACCEPT

• Person who has spent 1 year or more in total including living, working or on holiday in the United Kingdom, including Northern Ireland, England, Scotland, Wales, the Channel Islands or the Isle of Man in the period 01 January 1980 to 31 December 1996, other than for plasma for fractionation

 PERMANENTLY EXCLUDE:

• Classical CJD or variant CJD (vCJD) or other TSE
• Persons who have in the past been treated with extracts derived from human pituitary glands
• Persons who have received other pituitary extracts of human origin e.g. human  gonadotrophins (used as infertility treatment) or human thyroid –  stimulating hormone (Thyrotropin)
• Persons with intracranial tumours even if benign, if they have been treated with human desmopressin
• If had corneal grafts, or scleral grafts or other ocular tissue grafts
• If have been told that they have a family history of Classical CJD or other TSE other than vCJD.  A family history is defined as a history of Classical CJD or other TSE in any blood relative
• Recipients of dura mater grafts
• Persons who have had brain or spinal cord surgery in the UK on or after 01 January 1980
• Persons who have undergone burr hole surgery in the UK on or after 01 January 1980
• Persons who have undergone any spinal surgery in the UK on or after 01 January 1980 where the spinal cord was damaged or the dura mater was breached
• Persons who have had an inoculation injury with material containing abnormal prions
• Recipients of blood transfusions outside of the Republic of Ireland at any time (other than autologous transfusions)
• Recipients of blood transfusions in the Republic of Ireland on or after 1 January 1980 (other than autologous transfusions)
• Persons who have had a plasma exchange performed in or outside of the Republic of Ireland at any time
• Persons who have received intravenous immunoglobulin in the United Kingdom on or after 01 January 1980
• If a person has received donated eggs or embryos since 01 January 1980
• If a person had a homologous tissue (including bone) or homologous cell transplant in or outside the Republic of Ireland at any time
• Persons who have been told that they have been put at increased risk of vCJD from surgery, transfusion or transplant of tissues or organs
• Persons who have been told that they may be at increased risk of vCJD because a recipient of their blood or tissues has developed a prion related disorder
• Permanently exclude persons who have had a plasma exchange performed in or outside of the Republic of Ireland at any time

NOTES

A family history of variant CJD is not a reason for deferral. If a person has a family history of Classical CJD or other TSE and, following genetic counselling, they have been informed that they are not at risk, accept, following confirmation with a Donor Consultant / Consultant Haematologist or their nominees. If a person has a family history of Classical CJD that was due to a defined cause e.g. pituitary extract or dura mater graft, they can be accepted, following confirmation with a Donor Consultant / Consultant Haematologist or their nominees

SEE IF RELEVANT

• BLOOD TRANSFUSION
• DENTAL TREATMENT
• DURA MATER GRAFTS
• LASER TREATMENTS
• NEUROLOGICAL OPERATIONS
• NEONATAL CRITERIA