Rinn Advanced Therapies, is a new Research Ireland Centre, launched in June 2026. It will focus on the development and manufacturing of personalised advanced cellular immune therapeutics (ACITs). These newly emerging and rapidly advancing therapies are life-saving treatments for various chronic illnesses such as cancer and autoimmune diseases. Delivering ACITs to patients requires must be underpinned by research that integrates, therapy design, manufacturing, regulation, and clinical trials.
Rinn Advanced Therapies believes in ‘moving cells, not patients’ and collaboratively building towards achieving its mission of delivering the 'right therapy, at the right dose, to the right patient, at the right time'.
Centre Directors
Professor Athanasios Mantalaris, Professor Owen Smith, Professor Aideen Ryan
Rinn Advanced Therapies - REGULATE
Allison Waters, Irish Blood Transfusion Service & UCD School of Public Health, Physiotherapy and Sports Science, and Elaine Harris, Technological University Dublin, are co-leading the REGULATE research pillar, and bring together the expertise of Deirdre D'Arcy, Adriele Prina Mello, Cristin Ryan, Vincent Kelly, Bernard Naughton and Nicola Gardiner of Trinity College Dublin, Trinity Translational Medicine Institute, TCD and St James's Hospital Dublin.
Collectively the REGULATE team aims to:
- Incorporate model-informed drug development into regulatory evaluation to facilitate safety and efficacy assessment through all phases of therapy development.
- Generate and validate advanced ACIT cytokinetic and cytodynamic modelling approaches.
- Determine the optimum role of the Blood & Tissue services in the delivery of ATMPs by identifying where in the therapeutic pathway, from donor recruitment to cell manufacture to patient treatment, the IBTS can best contribute.
- Repurpose un-transfused and previously discarded donated material for cell manufacture.
- Generate in vivo translational models that integrate with organoid, organ-on-chip and regulatory assessment platforms, to support the safe and effective development of ACITs
- Develop and validate a ‘regulatory readiness tool’ to facilitate compliance, and ultimately authorisation, of putative therapies throughout the manufacturing process.
Research Ireland Award
€51,057,588.00
Coordinating institution
Trinity College Dublin