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HLA Variation and Disease

Human Leukocyte Antigen (HLA) Variation and Disease

Aims

To determine the distribution of Human Leukocyte Antigen (HLA) genotypes in Irish Donors
To compare donor HLA profiles with those required by transplant recipients
To investigate the associations between HLA types and disease presentation and progression

Key findings

The use of HLAMatchmaker to select platelet units for thrombocytopaenic HLA-alloimmunised patients produced satisfactory platelet increments.
- Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond. C O'Rafferty, G Rooney, Richard Hagan, M Woolfson, Diarmaid O'Donghaile, Joan Fitzgerald. Transfus Med. 2017 Oct;27 Suppl 5:369-374.

On-going Research

Case-control study investigating HLA genetic predisposition to the development of pseudotumours around hip resurfacings
Association of HLA with progression of paediatric type 1 diabetes
Link between paediatric hepatitis of unknown origin and HLA.

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