Health Research Project that use Donated Material

Institution

Principal Investigator

Health Research Aim

Research Ethics Reference Number

Donated Material

Donor Data Shared with Health Researcher

Donation ID

Date of Donation

Blood Group

Donor Age

Donor Gender

Dublin City University

Achilleas Floudas

Examine the role of the immune system and metabolism at the inflamed joint in order to identify novel opportunities for targeted therapeutic intervention for arthiritis

230523BSC - DCU

Buffy Coats, Whole Blood

x

x

X

Denis Collins

Examine the impact of intratumoural bacteria on the efficacy of targeted therapy using gastrointestinal cancer models and techniques.

DCUREC/2017/116

Buffy Coats

x

x

x

Karen English

Investigate the capacity for human mesenchymal stromal cells (MSCs) to suppress immune cell function.

BSRESC-2022-2482563

Buffy Coats

x

x

x

Maynooth University

Marion Butler

Age and Sex Differences in Immune Signalling Pathways

BSRESC-2021-2452643

Buffy Coats

x

x

x

x

x

Mark Robinson

Identify the glycans on immune molecules and determin their ability to interact with tumour cells.

REC 37562

Buffy Coats

x

x

x

Royal College of Surgeons of Ireland

Annie Curtis

Harness extracellular vesicles, derived from metabolically modulated macrophages, to promote the regenerative bone healing.

REC202303001

Buffy Coats

x

x

x

x

x

Gerard Curley

Develop a laboratory model for Acute Respiratory Distress Syndromw and examine the impact of novel therapeutics on injury

REC202405016

Whole Blood

x

x

x

Ingmar Schoen

Assess the impact of storage conditions on platelet function and clearance

RCSI REC202301015

Platelets

x

x

x

James O’Donnell

Investigate how ABO sugar antigens on Von Wilebrand Factor (VWF) influence its biological function and clearance.

REC1315 and AE19136/P040

Buffy Coats, Plasma

x

x

x

Marco Monopoli

Expose nano partices to donated plasma and understand how their behaviour changes.

REC 1246b

Plasma

x

x

x

Roger Preston

Examine the hyper coagulable and immunothrombotic state evident in Myeloproliferative Neoplasms Patients

SJH/TUH/JREC/2315

Buffy Coats

x

x

x

Technological University of Dublin

Claire Wynne

Role of Platelet-Derived Extracellular vesicles in tranfusion

LEWS-024-225

Platelets

x

x

x

x

x

Trinity College Dublin

Aideen Long

CharacteriseT  cell responses to viral peptides in patients with Long COVID

REC 20-012-AF1/COV

Buffy Coats

x

x

x

David Hoey

Investigate the contribution of dynamic biophysical cues, predicted to occur during the early phase of bone repair, on human blood-derived macrophage.

2306_FSTEMREC_SPDH_2022

Buffy Coats

x

x

x

Fred Sheedy

To investigate how activation and training of monocytes and other innate immune cells to better respond to infection is affected by metabolic changes

TCDFSTEMREC_12082022_ML

Buffy Coats

x

x

x

Jacintha O'Sullivan

Investigate the new therapy of calcium electroporation in Barrett's Oesophagus

REC 0277

Buffy Coats

x

x

x

Jacintha O'Sullivan

The effects of electroporation on  the secretome of  explant models of  gastrointenstinal cancers

2023-Apr-27372737 Upper GI , 2023-Mar-26532653 Lower GI

Buffy Coats

x

x

x

Jean Fletcher

Characterising immune and metabolic pathways in  inflammatory skin disease

BI-AP-300924a

Buffy Coats

x

x

x

Joanne Lysaght

Profile the immune component of pre-malignant pancreatic cysts for earlier detection and diagnosis of pancreatic cancer

2023-Mar-26532653

Buffy Coats

x

x

x

Joseph Keane

Study the immune cell responses to infection with mycobacteria, SARS CoV-2 and other pathogens.

REC 20230102

Buffy Coats, Whole Blood

x

x

x

Luke O'Neill

Examine the effect of metabolism within the cells on the innate immune response.

BI-AMG-300924

Buffy Coats

x

x

x

Mary Canavan

Understand the metabolic pathways that are involved in immune cell activation, differentiation and proliferation.

REC 2951

Buffy Coats

x

x

x

Michael Monaghan

Develop an in vitro drug screening platform for Mycardial Infarction.

Faculty of STEM- TCD 2022-06-07

Buffy Coats

x

x

x

Nicola Gardiner

Monitor the patients' immune function following cellular therapy (CAR-T)

REC 0535

Buffy Coats

x

x

x

x

x

Padraic Fallon

The blood will be used as healthy controls in research project on Haemophilia

REC 20180403

Whole Blood

x

x

x

Rachel McLoughlin

Understand the host immune reponse to and immunomodulatory capacity of Staphlococcus aureus infection.

REC 140622

Buffy Coats

x

x

x

Aisling Dunne

Investigate the immune response to inflammatory stimuli, relevant to various inflammatory diseases

B1-LS-010923

Buffy Coats

x

x

x

Clair Gardiner

Understand how Natural Killer (NK) cells work and are how they regulated in healthy normal individuals

TCDFEMSREC_ 02032020_Gard_Slat

Buffy Coats, Whole Blood

x

x

x

Eric Downer

Assess innate immune signature in immune cells from control cases, and individuals with disease.

REC REF: 16/47 / 3503

Buffy Coats, Whole Blood

x

x

x

Kathy Gately

Characterise liquid biopsy in patients with lung cancer and healthy individuals

REC 041018/8804

Buffy Coats, Plasma, Whole Blood

x

x

x

Lorraine O'Driscoll

Investigate the effect of gastric cancer patient plasma derived extracellular vesicles (EVs) on T-cells

2023-Mar-26532653 (Project ID if needed is 215)

Buffy Coats

x

x

x

Melissa Conroy

Investigate the effect of in vitro cytokine treatment on healthy donor naturl killer cells

2023-Mar-26532653 (Project ID 215)

Buffy Coats

x

x

x

Sarah Doyle

Characterise the role of the immune system in Age-related Macular Degeneration

REC 210308

Buffy Coats

x

x

x

Sharee Basdeo

Characterise the interplay between myeloid and lymphoid cells in healthy people and those during and post disease.

REC 20200802

Buffy Coats

x

x

x

Viviana Marzaioli

Characterise the functionality of Rheumatoid Arthritis and Psoriatic Arthritis derived monocytes

SVUH REC approval granted,

Buffy Coats

x

x

x

University College Cork

Cathriona Foley

Characterse postoperative inflammation and wound healing.

ECM 4 (f) 28/03/2023

Red Cell Concentrate, Buffy Coats, Platelets, Plasma, Whole Blood

x

x

x

Fergus McCarthy

Non-invasive detection of lactate using bio-photonics in whole-blood

ECM 4 (r) 06/02/20

Red Cell Concentrate, Buffy Coats, Platelets, Plasma, Whole Blood

x

x

x

Jens Walter

 We are studying how bacteria and their metabolites influence the immune system.

REC 2302

Buffy Coats, Whole Blood

x

x

x

Liam O'Mahony

Investigate how bacterial components and metabolites influence innate and adaptive immune responses.

REC 2301

Buffy Coats

x

x

x

Subrata Ghosh

Understand how the gut microbiome regulates inflammatory bowel disease

REC 2303

Buffy Coats

x

x

x

Vitaliy Mykytiv

Role of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in coagulation and haemostasis.

ECM 4 (a) 01/08/2023

Buffy Coats

x

x

x

John Higgins

Quantify blood loss during obstetric complications.

ECM 4 (q) 12/09//2023 & ECM 3 (r) 24/10/2023

Whole Blood

x

x

x

University College Dublin

Adam Byrne

Monocyte and Macrophage Metabolism in Lungs.

SVUH REC 05/03/2025

Buffy Coats, Whole Blood

x

x

x

Eoin Cummins

Investigation of the effect of hypoxia and hypercapnia on human immune cells

RS19-079

Buffy Coats, Whole Blood

x

x

x

Fiona Freeman

Develop novel therapeutics for pediatric bone cancer, osteosarcoma

LS-LR-24-199-Odonoghue-Freeman

Buffy Coats

x

x

x

Guenther Eissner

Investigate the COVID-19 effect on lung endothelial cells

RES 528

Buffy Coats

x

x

x

Margaret Mc Gee

Investigate the role of extracellular vesiciles in B cell malignancies

LS-E-21-115-Sheridan-McGee

Buffy Coats, Whole Blood

x

x

x

Michael keane

PBMC isolation from buffy coat to then isolate fibrocytes for primary cell cultire

RES 528

Buffy Coats

x

x

x

Virginie Gautier

Develop novel HIV Cure strategies that target and reduce the size of the HIV reservoirs

LS-LR-22-246-dAutume-Gautier

Buffy Coats

x

x

x

University of Galway

Daniel O'Toole

Characterise the immunomodulatory properties of different cell types

C.A. 3199

Buffy Coats

x

x

x

John P. Dalton

Investigate the therapeutic potential of helminth-derived immunomodulatory properties in the treatment of inflammatory diseases.

REC 2022.10.018

Buffy Coats

x

x

x

Karen Doyle

Characteriste stroke clots to better leading to new and improved stroke treatments.

REC 17-MAR-06

Buffy Coats, Platelets, Whole Blood

x

x

x

Radka Fahey (Saldova)

Investigate the role of glycosylation on T-cells function

277-LS-SD-25-Fahey

Buffy Coats

x

x

x